In women underneath the ages of twenty five years, high educational top (Otherwise 2.6, 95% CI step one.1–6.1), and more than a single regular (Or 2.1, 95% CI 1.1–4.1) or relaxed (Otherwise 1.seven, 95% CI step one.0–2.9) sexual lover predict problems chance (Dining table 4). There’s as well as a suggestion from an increased risk having current the means to access dental contraceptives (Or dos.0, 95% CI 0.6–step one.5 – Table 4). The addition of female going to a teen infirmary (age thirteen–17 many years) don’t create a bias on study abilities, while the zero mathematically significant differences were found when they had been omitted regarding data. This new connection that have number of couples proceeded which have a slightly straight down opportunity proportion (Otherwise step 1.eight, 95% CI 0.7–cuatro.2). On top of that, this new association having knowledge try stronger (Or seven.cuatro, 95% CI step 1.9–30.0 getting advanced away from studies).
9, 95% CI step 1.step 3–step 3.0 – Table cuatro). Former accessibility oral contraceptives increased the new infection exposure a bit (Or step 1.6, 95% CI step 1.0–dos.5) and you can parity a bit decreases the risk (Or 0.5, 95% CI 0.2–step one.2). No clear trend from connection is actually observed certainly one of feminine aged 35 or more ages. The analysis had not enough female of one’s ages of 55 decades or more so that next subgroup research with important analytical energy.
Young age and advanced out-of hit studies was indeed better predictors out of numerous problems than just from solitary ones (Desk 5). Getting multiple infection, there is a development having a protective aftereffect of parity (for three or higher students versus nulliparous, Otherwise 0.5, 95% CI 0.2–step 1.3) and employ off condoms (Or 0.5, 95% CI 0.3–0.9) (Dining table 5). Most of the time, yet not, checked-out characteristics common equivalent relationships that have single and you can several problems.
Discussion
To date, couple knowledge examined decades-specific HPV incidence patterns and you may determinants out-of HPV problems certainly women with normal cytology inside the regions with high incidence regarding cervical cancers. We statement right here the initial data of this kind done in Colombia. An overall HPV DNA frequency regarding 14.9% is actually receive, which is exactly like one to claimed various other higher-chance communities during the Mexico (fourteen.5%) (Lazcano ainsi que al, 2001) and you may Costa Rica (16%) (Herrero mais aussi al, 2000). Concurrently, it is similar to the new HPV-DNA prevalence certainly manage female (13%) in the good concurrent circumstances–handle studies for the Cali, Colombia (Munoz mais aussi al, 1996).
There was no clear association within existence of relaxed sexual lovers, ages to start with sexual intercourse or basic beginning, entry to IUDs or condoms and you will chance
Numerous research has suggested the incidence from HPV problems decrease as we grow older, HPV becoming unusual into the cytological typical female over age thirty-five ages (Melkert mais aussi al, 1993; Morrison, 1994). Yet not, a number of recent high society-dependent surveys away from Costa Rica and you will Mexico in addition to exhibited specific increase inside HPV disease one of feamales in peri- and you can post-menopause decades. Whilst in Costa Rica the brand new height is actually seen in women earlier than 55 ages, that have an effective predominance regarding LR HPV models, from inside the Mexico the second top started earlier, immediately after forty-five years of age, having predominance off Hr HPV products and with a rise in identification off LR HPV versions compared to more youthful many years.
Inside our analysis the fresh HPV prevalence about generation forty hvordan fГҐr jeg en postordrebrud five–54 years try reduced, however, there can be a greater prevalence of HPV disease in females aged 55 or maybe more age, having a good predominance out-of LR designs and you may numerous HPV problems, but nonetheless 5.7% was in fact Hour HPV confident. In the event that affirmed, the risk of HPV infection – most notably LR designs – among blog post-menopausal women, it can be informed me differently: (1) reactivation away from hidden HPV attacks by decreased immune reaction. Certain immunological research has shown a decrease in distributing mature T structure in the elderly right down to a reduction in CD8+ lymphocytes, a fall on the regularity away from CD4+ T muscle producing IL-2 and you may/or a minimal term when you look at the IL-2 receptors (Lesourd and you can Meaume, 1994; Gostout ainsi que al, 1998; Ginaldi mais aussi al, 1999). (2) Reactivation from hidden HPV bacterial infections of the hormonal changes associated with the brand new gradual refuse from ovarian mode doing menopause (Lazcano et al, 2001). (3) A cohort perception (Herrero et al, 2000), where elderly women was indeed met with herpes at the beginning of life and belonged to help you years a whole lot more heavily confronted by HPV attacks.